^^
Well, it can be quite funny.

Ted: "Hey, Jimbob, what's with the long ears?"
Jimbob: "My mom's a Lopunny. How? Don't ask."

Of course, I'm driven away from the sci-fi thing, but it could work out like this.

Ted: "Hey, Jimbob, what's with the pixellated nose?"
Jimbob: "I got fused with a Porygon. How? Don't ask."

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